Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss
Status:
Completed
Trial end date:
2018-12-01
Target enrollment:
Participant gender:
Summary
Recurrent unexplained spontaneous miscarriage (RSM) is defined as three consecutive pregnancy
loss prior to 20 weeks from the last menstrual period. 1% to 2% of women experience RSM.
Treatment of URSM is a challenging issue. The currently available lines of treatment
according to simplicity of use, reliability and degree of invasiveness include
corticosteroids, sildenafil citrate, aspirin, heparin and immunoglobulins (besides good
antenatal care), but up to now there are no prospective randomized studies, powerful enough,
to determine a significant difference between these therapeutic protocols, with any of the
above mentioned pharmacological agents.
Sildenafil Citrate (Viagra®), a vasodilator, is also described as an anti-inflammatory agent.
While improving uterine blood flow in the proliferative phase, NO may have detrimental
effects at the level of the endometrium during the implantation window. The NO- mediated
release of cytokines such as tumour necrosis factor- from activated natural killer cells has
been implicated as a cause of implantation failure.
Based on these observations, this study attempts was made to study uterine arteries and
sub-endometrial blood flow during the luteal phase in normal fertile women and in patients
with Unexplained recurrent miscarriage
Phase:
Phase 1
Details
Lead Sponsor:
Ain Shams University
Treatments:
Citric Acid Folic Acid Sildenafil Citrate Vitamin B Complex