Sildenafil Therapy In Dismal Prognosis Early-Onset Intrauterine Growth Restriction
Status:
Terminated
Trial end date:
2019-04-01
Target enrollment:
Participant gender:
Summary
Early-onset placental intrauterine growth restriction (EO IUGR) is associated with a high
risk of perinatal morbidity and mortality. In association with reduced circulating placental
growth factor (PlGF) EO IUGR results from abnormal placentation with inadequate remodelling
of the maternal uteroplacental arteries. There is no known treatment for placental IUGR.
Management involves intensive fetal surveillance with delivery with evidence of serious fetal
compromise. However, remote from term, delivery is associated with significant perinatal
mortality and morbidity. Sildenafil vasodilates the uteroplacental vessels of IUGR-affected
pregnancies and may represent a novel therapy.