Sildenafil for Swimming-Induced Pulmonary Edema (SIPE) Prevention

• Status: Enrolling by invitation
• Trial end date: 2022-01-31
• Target enrollment: 0
• Participant gender: All

Summary

This trial is testing the effectiveness of a single oral dose of sildenafil (50 mg) taken 1 hour before a provocative event on the subsequent development of swimming-induced pulmonary edema.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Duke University
• Collaborator: United States Department of Defense
• Treatments: Sildenafil Citrate

Criteria

Inclusion Criteria:

• Healthy volunteers between 18 and 45 years

• History of swimming-induced pulmonary edema

Exclusion Criteria:

• Pregnant women

• Significant heart valve disease

• Cardiomyopathy

• Uncontrolled hypertension

• Coronary artery disease

• Obstructive lung disease

• VO2max <25 mL/kg as estimated by the University of Houston Non-Exercise Test

• Previous adverse reaction to sildenafil

• Use of antihypertensives or other drugs that are known to interact adversely with sildenafil (e.g. nitrates, alpha adrenergic blockers)