Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections

• Status: Unknown status
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

A simplified graded gut decontamination protocol combined with rigorous bi-weekly screening and appropriate bacterial prophylaxis, will lead to a 25% reduction in the acquisition of blood stream infections and to a 25% reduction in lower airway colonization with multi drug resistant organisms. There will be no concomitant rise in gram-positive or fungal infection or a surgency of new resistance patterns.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Colistin; Neomycin; Nystatin; Vancomycin

Criteria

Inclusion Criteria:

1. Expected to be in the ICU > 72 hours

2. Has an enteral feeding tube and can receive enteral medication

3. Has a tracheal tube

Exclusion Criteria:

1. Pt. is moribund - not expected to survive > 28 days

2. Pt. or legal representative refuse to participate