Simultaneous Versus Sequential Antiretroviral Therapy (ARV) Therapy and Mycobacterium Tuberculosis (MTB) Treatment

• Status: Terminated
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate and compare the efficacy of immediate antiretroviral therapy versus 2 month deferred anti-Tb therapy upon the clinical course of tuberculosis and HIV infection in patients with AIDS and active tuberculosis.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Enfermedades Respiratorias
• Collaborator: Consorcio de Investigación sobre VIH/SIDA/TB (CISIDAT).
• Treatments: Antitubercular Agents; Efavirenz; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Isoniazid

Criteria

Inclusion Criteria:

• HIV infected

• < 200 CD4+ cells/mL

• Active pulmonary tuberculosis (with or without extrapulmonary involvement)

Exclusion Criteria:

• Meningeal tuberculosis

• Unable to attend 96 wk follow-up