Simvastatin as Inhibitor of Cell Adhesion Mediated Drug Resistance in Patients With Refractory Multiple Myeloma.
Status:
Completed
Trial end date:
2007-04-01
Target enrollment:
Participant gender:
Summary
In vitro statins, inhibitors of the HMG-CoA-reductase, have been shown to overcome cell
adhesion mediated drug resistance at very low concentrations. The purpose of the study is to
investigate the in vivo efficacy of simvastatin as inhibitor of cell adhesion mediated drug
resistance. Patients refractory to ongoing chemotherapy will receive concomitantly
simvastatin and response will be monitored by paraprotein levels