Single Dose Omeprazole Versus High Dose in High-risk Critically Ill Patients.
Status:
Completed
Trial end date:
2017-09-17
Target enrollment:
Participant gender:
Summary
Upper gastrointestinal (GIT) bleeding is common in high risk critically ill patients.
Hyperacidity has been identified as one of the main reasons for bleeding.1 2 Antacids with
different treatment modalities have been studied to establish the best regimen for
prophylaxis against bleeding.3 4 Proton pump inhibitors (PPI) are the most common drugs used
in the medical field as antacids. The present study was carried out to investigate the
beneficial effects of high dose omeprazole versus standard low dose as a prophylaxis against
upper GIT bleeding in high risk critically ill patients.