Single Dose Steroid Before Thyroidectomy for Benign Disease to Improve Postoperative Nausea, Pain, and Vocal Function

• Status: Unknown status
• Trial end date: 2012-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the efficacy of 8 mg of dexamethasone administered prior surgery, to reduce pain, postoperative nausea and vomiting and to improve vocal function after thyroidectomy for benign disease.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ospedale Misericordia e Dolce
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Age > 18 years

• Patients undergoing thyroidectomy

Exclusion Criteria:

• Patients who had received antiemetic therapy within 48 hours before surgery

• Patients with depression

• Chronic pain disorder

• Insulin-dependent diabetes mellitus

• History of severe and/or repeated PONV after previous minor surgery, that led to change from standard anesthetic protocol

• Pregnancy

• Age < 18 years

• Patients who had known malignant disease or had undergone previous thyroid or neck surgery