Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Several modalities have been studied to prevent coughing during emergence, including extubation in a deep plane of anesthesia but have proved to be unreliable. So far, no reliable method is recommended as standard of care. The advantages of administering tramadol includes a long duration of action, rapid recovery, limited depression of respiratory function and no effect on platelet makes it a safe medication to use for neurosurgical patients after craniotomy. The primary objective of the study is to observe the effect of single dose of tramadol (1mg/kg) administered 45 minutes before extubation on hemodynamic response (measurement of B.P and H.R) during extubation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Aga Khan University
• Treatments: Tramadol

Criteria

Inclusion Criteria:

• Patients with craniotomy for supratentorial tumors under general anesthesia

• American Society of Anaesthesiologists (ASA) 2 and stable ASA 3 patients

• Elective surgery

• Patients with Glasgow Coma Scale (GCS) 15/15

Exclusion Criteria:

• Patients with a history of allergy or hypersensitivity to tramadol.

• History of epilepsy or convulsions due to any reason.

• Chronic usage of analgesic drugs.

• Patients using monoamine oxidase inhibitors.

• Patients with clinical signs of raised ICP.

• Obesity (women with a body mass index >35 kg/m2 or men with a body mass index >42 kg/m2)

• Language barrier.

• Patients taking B-blockers or Ca channel blockers.

• Patients above 65 years of age ( Physiology difference)