Single Injection of Dexamethasone for Acute Bronchiolitis in Young Children

• Status: Completed
• Trial end date: 2004-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to determine whether a single intramuscular injection of dexamethasone decreased the duration of symptoms of acute bronchiolitis in young children.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Khon Kaen University
• Collaborator: National Research Council of Thailand
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Aged 4 weeks - 24 months

• Has the first episode of wheezing within 7 days

• Has evidence of viral infection

• Requires hospital admission; criteria for admission include one of the following: age < 3 months; respiratory rate > 60 breaths/minute for age < 12 months or 50 breaths/minute for > or equal to 12 months; oxygen saturation in room air < 95% and apathy or refuses feeding.

Exclusion Criteria:

• Initial admission to intensive care unit

• Initial requirement for endotracheal intubation or mechanical ventilation

• A previous history of intubation

• A known history of asthma or response to the first dose of beta2 agonist nebulization

• A history of prematurity

• A history of bronchopulmonary dysplasia or chronic lung disease

• Underlying congenital heart disease or immunodeficiency

• Receives treatment of any form of corticosteroids within 2 weeks

• Has contraindication to corticosteroid treatment