Single Photon Emission Computed Tomography (SPECT) Imaging Study to Develop a Biomarker for Alzheimer's Disease
Status:
Terminated
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
The main objectives of this proposal are as follows:
- To assess the dynamic uptake and washout of 123-I MNI-388 and MNI 390, a potential
imaging biomarker for β-amyloid burden in brain, using single photon emission computed
tomography (SPECT) in similarly aged Alzheimer's (AD) subjects and healthy controls
- To perform blood metabolite characterization of 123-I MNI-388 and MNI-390 in healthy and
AD subjects to determine the metabolic fate and nature of metabolites in assessment of
123-I MNI-388 and MNI 390 as a single photon computed tomography (SPECT) brain imaging
agent