Single Versus Double Dose Intra-vaginal Prostaglandin E2 "Misoprostol" Prior Abdominal Myomectomy
Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
Introduction: The study aimed to investigate the effectiveness of a single versus double dose
of Prostaglandin E2 "Misoprostol, 400 microgram" during myomectomy for multiple uterine
fibroids. This was a prospective randomized controlled trial comprised of 69 patients with
multiple myomas undergoing myomectomy. Patients randomly allocated to either an intra-vaginal
single dose of 400 microgram Misoprostol 1 hour pre-operatively (group A, 34 cases) or 2
doses, 3 and 1 hours, prior surgery (group B, 35 cases). Operation time, intra and
post-operative blood loss, hemoglobin concentration, blood pressure and body's temperature
were estimated and compared in both groups.