Both glucocorticoid and sinomenine are widely used in the routine clinical treatment of
osteoarthritis, but there is still a lack of high level of clinical evidence for the direct
comparison of efficacy between the two drugs. This trial aims to evaluate whether
intraarticular injection of sinomenine was noninferior to intraarticular injection of
glucocorticoid for symptom relief in patients with early knee arthritis, and whether
intraarticular injection of sinomenine was superior to intraarticular injection of
glucocorticoid for changes in tibial cartilage volume (measured by mean thickness) from
baseline compared with intraarticular injection of glucocorticoid. 326 people will
participate in the study at 3 different research/medical institutions, with centres competing
for inclusion. This trial was designed by random blind method. This trial will last for 2
years and participants will receive 6 injections every 4 months.