Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia
Status:
Unknown status
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Aplastic anemia is a rare autoimmune disorder in which the bone marrow production of blood
cells is greatly decreased or absent. Symptoms include fatigue, weakness, tiny reddish-purple
marks on the skin, abnormal bruising, and bleeding from the gums, nose, or intestine. While
some cases of aplastic anemia are caused by medications, toxic exposures, or inherited genes,
most often the cause remains unknown. The purpose of this study is to determine the safety
and efficacy of combining two drugs, sirolimus and cyclosporine, for treating individuals
with aplastic anemia that has not responded to other treatments.