There is an increased risk for sleep disordered breathing (SDB), sleep-related
hypoventilation and irregular breathing in individuals on chronic prescription opioid
medications. Almost 30% of a veteran sleep clinic population had opioid-associated central
sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be
effective in reducing unstable breathing and eliminating sleep apnea in chronic opioid use
via different mechanisms. We will study additional clinical parameters like quality of life,
sleep and pain in patients with and without opioid use. This proposal will enhance the
investigators' understanding of the pathways that contribute to the development of sleep
apnea with opioid use. The investigators expect that the results obtained from this study
will positively impact the health of Veterans by identifying new treatment modalities for
sleep apnea.