Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis
Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
The main purpose of this trial is to test if mortality of childhood bacterial meningitis can
be reduced by slow, continuous infusion of cefotaxime initially, instead of the traditional
bolus administration four times daily (qid), combined with high-dose paracetamol orally, when
both treatments are executed for the first 4 days. The series will be collected at Hospital
Pediátrico David Bernardino, Luanda, Angola.
The recruitment of patients begins, the conditions permitting, in early 2012. The criteria
for patient participation is a child at the age of 2 months to 15 years who presents with the
symptoms and signs suggestive of bacterial meningitis, for whom a lumbar puncture is
performed, and the cerebrospinal fluid analysis suggests bacterial meningitis.