Small-dose Dexmedetomidine Effects on Recovery Profiles of Supratentorial Tumors Patients From General Anesthesia
Status:
Unknown status
Trial end date:
2014-12-01
Target enrollment:
Participant gender:
Summary
An excellent recovery profile is critical for neurosurgical anesthesia. Rapid awakening,
smooth blood pressure and heart rate (HR), a higher degree of coordination, painless or mild
pain, as well as better tolerance to endotracheal intubation can avoid can increased
intracranial pressure, elevated blood pressure and rapid HR caused by emergency choking,
suffocation and agitation, and can reduce postoperative cerebral edema and the risk of
bleeding. In addition, it is easy for surgeons to timely evaluate postoperative patients'
neurologic function based on the excellent recovery from anesthesia. Up to now, there are
many methods and drugs to improve the quality of recovery period, but each of them has some
flaws. Dexmedetomidine, an emerging anesthetic adjuvant, exhibits a stable hemodynamic
recovery period, and cannot affect evaluation of neurological function with both the sedative
and analgesic effects. We propose the following hypotheses: (1) A small dose of
dexmedetomidine can be intravenously injected into patients subjected to craniotomy under
general anesthesia, in order to improve the recovery profiles and reduce the incidence of
emergence agitation. (2) Dexmedetomidine can reduce postoperative pain.