Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis

• Status: Not yet recruiting
• Trial end date: 2022-02-01
• Target enrollment: 0
• Participant gender: All

Summary

At present, people still have different opinions on choosing which kind of crystalloid solution for patients with sepsis, and there is no unified standard yet. It is necessary to conduct systematic studies on comparison of different fluid resuscitation methods on the efficacy and safety of crystalloid solution for patients with sepsis. Therefore, this study focuses on the efficacy and safety of sodium bicarbonate Ringer's solution compared with normal saline.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Xiangya Hospital of Central South University
• Treatments: Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Diagnosed as sepsis or septic shock according to the definition of Sepsis-3.0 with fluid resuscitation requirement;

• aged between 18 and 80, male or female;

• Signed informed Consent (with delay within 24 hours).

Exclusion Criteria:

• Patients with hypermagnesemia;

• Patients with hypothyroidism;

• Patients predicted to die or discharged within 24 hours after admission;

• Patients with previous history of mental illness, severe hepatic and renal insufficiency, severe cardiac disease, primary severe central nervous system lesions;

• Pregnant or breast-feeding women;

• Patients who have received cardiopulmonary resuscitation；

• Patients who participated in other clinical trials within 30 days;

• Patients have other conditions that are not appropriate for inclusion according to the researcher's judgment.