Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During Hepatectomy
Status:
Recruiting
Trial end date:
2023-03-30
Target enrollment:
Participant gender:
Summary
A variety of reasons lead to a sharp increase in lactic acid levels in patients undergoing
liver resection, while leading to hyperlactic acidemia, resulting in decreased cardiac
output, elevated blood potassium, and response to catecholamines and insulin Damage,
increased risk of kidney damage, poor recovery of liver function, decreased immune function,
and prolonged hospital stay. Sodium bicarbonate Ringer injection does not contain lactic
acid. HCO3- is metabolized by acid-base neutralization in body fluids, and 90% is CO2 The
form is excreted from the body by breathing, and only 10% HCO3- is metabolized by the kidney,
without the burden of liver metabolism. Physiological concentration of Cl- avoids perchloric
acidosis and kidney damage; physiological concentration of Ca2+ and Mg2+ help maintain the
body's electrolyte balance and reduce stress-related arrhythmia.The smooth development of
this study will help refine the intraoperative fluid management strategy, improve the
patient's intraoperative tissue perfusion, maintain the body's acid-base and electrolyte
balance, reduce postoperative kidney damage, and improve the patient's quality of life.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University
Collaborators:
Affiliated Hospital of Qinghai University First Affiliated Hospital of Xinjiang Medical University Henan Cancer Hospital Henan Provincial People's Hospital LanZhou University People's Hospital of Xinjiang Uygur Autonomous Region Shaanxi Provincial People's Hospital