Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery
Status:
Terminated
Trial end date:
2017-07-22
Target enrollment:
Participant gender:
Summary
The proposed study will investigate the effect of sodium bicarbonate on the prevention of
acute kidney injury in children undergoing cardiac surgery with cardio-pulmonary bypass. The
investigators hypothesize that the occurrence of acute kidney injury will be less in children
treated with sodium bicarbonate in the perioperative period when compared to placebo. The
specific aims of this proposal are as follows:
1. To institute a prospective, randomized, double-blinded, placebo-controlled trial in
pediatric subjects undergoing cardiac surgery to determine the efficacy of sodium bicarbonate
on prevention of acute kidney injury as measured by pRIFLE criteria. 2. To examine whether
treatment with sodium bicarbonate modifies the duration of acute kidney injury, fluid
balance, hospital length of stay, need for dialysis, and progression to kidney failure. 3. To
determine the relevance of NGAL as a biomarker to predict development of acute kidney injury.