Sodium Hyaluronate and Wavefront Aberrations in Dry Eyes
Status:
Completed
Trial end date:
2010-09-01
Target enrollment:
Participant gender:
Summary
Eyes with abnormal tear film function have been found to show larger optical aberrations than
normal eyes which may be attributed to the unstable and irregular tear film, uneven ocular
surface, and increased scatter due to the exposure of the rough surface of corneal epithelium
after tear break-up.
These hypotheses have been supported by the findings that instillation of artificial tears
(sodium hyaluronate preparation) in dry eye patients reduces both corneal and ocular
aberrations, improving the optical quality of the retinal image.
However, the previous studies only evaluated the short-term effects of a single
administration of an artificial tear but did not determine the duration of action or
inflection point at which the ocular aberrations increase back to baseline. Also, there has
clearly been no such clinical trial that has been a well randomized controlled study to date.
This report is the first randomized controlled trial that investigated the long-term effects
of a single dose of sodium hyaluronate-based artificial tears on wavefront aberrations in
patients with dry eye.