Sorafenib Combined With Cisplatin and Etoposide or Carboplatin and Pemetrexed in Treating Patients With Metastatic Solid Tumors

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Sorafenib and pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Sorafenib may also stop the growth of tumor cells by blocking blood flow to the tumor. Drugs used in chemotherapy, such as cisplatin, etoposide, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving sorafenib together with cisplatin and etoposide or carboplatin and pemetrexed may kill more tumor cells.

PURPOSE: This phase I trial is studying the side effects and best dose of sorafenib when given together with cisplatin and etoposide or carboplatin and pemetrexed in treating patients with metastatic solid tumors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UNC Lineberger Comprehensive Cancer Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Carboplatin; Cisplatin; Etoposide; Etoposide phosphate; Niacinamide; Pemetrexed; Sorafenib

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed metastatic solid tumor

• Disease progressed during at least one standard therapy OR has a disease for which there is no standard therapy

• No squamous cell carcinoma of the lung

• Asymptomatic brain metastases allowed provided both of the following criteria are met:

• Brain metastases were treated ≥ 6 months ago

• Brain metastases are clinically stable without steroid treatment for 1 week

• No clinically relevant pleural effusions or ascites that cannot be controlled by drainage (group 2)

PATIENT CHARACTERISTICS:

• ECOG performance status 0-1

• Hemoglobin ≥ 9.0 g/dL

• ANC ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

• ALT and AST ≤ 2.5 times ULN

• INR < 1.5 or PT/PTT normal

• Creatinine clearance ≥ 45 mL/min

• Negative serum pregnancy test

• Fertile patients must use effective contraception during and for at least 2 weeks after completion of study treatment

• No New York Heart Association class III or IV congestive heart failure

• No unstable angina (anginal symptoms at rest) or new onset angina (within the past 3 months)

• No myocardial infarction within the past 6 months

• No cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

• No uncontrolled hypertension, defined as systolic blood pressure > 150 mm Hg or diastolic blood pressure > 90 mm Hg, despite optimal medical management

• No known severe hypersensitivity to sorafenib tosylate or any its excipients, etoposide, pemetrexed disodium, cisplatin, or carboplatin

• No known HIV infection

• No chronic hepatitis B or C

• No active clinically serious infection > CTCAE grade 2

• No thrombotic or embolic events, such as cerebrovascular accident or transient ischemic attacks, within the past 6 months

• No pulmonary hemorrhage or bleeding event ≥ CTCAE grade 2 within the past 4 weeks

• No other hemorrhage or bleeding event ≥ CTCAE grade 3 within the past 4 weeks

• No serious non-healing wound, ulcer, or bone fracture

• No evidence or history of bleeding diathesis or coagulopathy

• No condition that impairs the patient's ability to swallow whole pills

• No malabsorption problem, uncontrolled inflammatory bowel disease, or gastrointestinal disorder causing ≥ 5 bowel movements in a 24-hour period

• No significant traumatic injury within the past 4 weeks

• Able to take vitamin B12 supplementation and folic acid (group 2)

PRIOR CONCURRENT THERAPY:

• More than 4 weeks since prior major surgery or open biopsy

• No more than 3 prior cytotoxic therapies for metastatic disease

• No concurrent St. John's wort or rifampin

• No non-steroidal anti-inflammatory drugs (NSAIDs) for 2 days before (5 days for long-acting NSAIDs), during, and for 2 days after pemetrexed disodium administration (group 2)

• Concurrent anticoagulation treatment with warfarin or heparin allowed