Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma
Status:
Completed
Trial end date:
2013-02-02
Target enrollment:
Participant gender:
Summary
This phase I/II trial studies the side effects and best dose of temsirolimus when given
together with sorafenib tosylate and to see how well they work in treating patients with
glioblastoma that has come back. Sorafenib tosylate may stop the growth of tumor cells by
blocking blood flow to the tumor. Drugs used in chemotherapy, such as temsirolimus, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Sorafenib tosylate and temsirolimus may also stop the growth of tumor
cells by blocking some of the enzymes needed for cell growth. Giving sorafenib tosylate with
temsirolimus may kill more tumor cells.