Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
Status:
Not yet recruiting
Trial end date:
2026-04-30
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the
production of anti-inflammatory effects and clinical improvement in people with depression
who have not responded well to standard antidepressant treatment. The main questions it seeks
to answer are:
1. Do omega-3 fatty acids added to ineffective antidepressant treatment increase production
of compounds that reduce inflammation?
2. Is the increase in these anti-inflammatory compounds associated with a stronger
antidepressant effect?
Participants taking antidepressants that have not worked completely will be assigned at
random for a 12-week period to one of the following:
1. an omega-3 preparation
2. an inactive placebo
During the course of the study, blood tests will be obtained for compounds associated with
inflammation, and questionnaires to measure clinical improvement in depressive symptoms will
be administered.