Spectroscopic Imaging at 4T: A Drug Challenge Study
Status:
Terminated
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
An advanced technique for rapid magnetic resonance proton spectroscopic imaging (1H-MRSI)
will be employed in a drug challenge study in healthy volunteers to spatially map and measure
acute changes in the brain chemicals GABA, glutamate and glutamine after administration of a
drug. Three condition will be tested in a double-blind fashion, i)depressant, ii)stimulant,
iii)placebo. It is hypothesized that unique and reproducible spatial and directional
metabolic response patterns will be observed, unique to each condition within the brain.