Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery

• Status: Completed
• Trial end date: 2018-08-14
• Target enrollment: 0
• Participant gender: All

Summary

Spine surgery is one of the most common operative procedures in the United States. It is performed in the prone position (a patient laying on belly). Muscle relaxants are given for neuromuscular blockade often referred as paralysis for surgical exposure which is maintained until the patient is returned to the supine position (a patient laying on back) at the end of surgery. At the end of the surgery the paralysis is reversed with a drug (neostigmine). A new drug (sugammadex) has the ability to rapidly reverse the paralysis but it is not well investigated in elderly. This study will investigate speed of recovery and complications of the two reversal drugs in elderly patients (age ≥ 65 years) undergoing posterior spine surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Missouri-Columbia
• Collaborator: Merck Sharp & Dohme Corp.
• Treatments: Neostigmine

Criteria

Inclusion Criteria:

1. Posterior spinal surgery

2. Age ≥ 65 years

3. American Society of Anesthesiologists (ASA) grade I-III

Exclusion Criteria:

1. Inability to obtain written informed consent

2. Allergy to rocuronium or anesthetic agents used in the protocol

3. Known or suspected neuromuscular disorders

4. Significant renal disease with a serum creatinine ≥ 2 mg/dl

5. Significant liver disease

6. A family history of malignant hyperthermia