Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection
Status:
Completed
Trial end date:
2014-08-01
Target enrollment:
Participant gender:
Summary
Klinefelter syndrome KS is caused by an additional X chromosome in males (47,XXY). Clinical
findings are nonspecific during childhood; thus, the diagnosis commonly is made during
adolescence or adulthood in males who have small testes with hypergonadotropic hypogonadism
and gynecomastia. Virtually all men with Klinefelter syndrome are infertile.
Approximately one in 1,000 boys is born with an additional X chromosome-47,XXY, the karyotype
that causes Klinefelter syndrome. This karyotype is detected at or before birth in 10 percent
of affected boys, and it is found during adulthood in 25 percent of affected men. Almost all
men with a 47,XXY karyotype will be infertile; Klinefelter syndrome accounts for 3 percent of
male infertility.
Klinefelter syndrome is common in infertile men with oligospermia or azoospermia (5 to 10
percent).
Infertility in men with Klinefelter syndrome is caused by a precipitous drop in sperm count.
If sperm are present, cryopreservation is useful for future family planning with
intracytoplasmic sperm injection, and if not, testicular sperm extraction may be pursued.
Although there have been multiple reports of successful fertilization by men with Klinefelter
syndrome.
Mesenchymal stem cell injection in testicular tubules and intra testicular artery using
surgical microscope.
The period for follow up last from three months to twelve months including semen analysis to
detect sperm and hormonal profile .
Phase:
N/A
Details
Lead Sponsor:
Man Clinic for Andrology, Male Infertility and Sexual Dysfunction