Spirometry and Methacholine Challenge Test in Asthmatic Children Age 3-6years

• Status: Terminated
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

Rational: The possible contribution of methacholine challenge test via spirometry to the clinical diagnosis of young children with various respiratory symptoms, the most appropriate spirometry index, and the proper cutoff point concentration that will define airway sensitivity have not yet been explored. Objectives: To assess airway reactivity by spirometry in a large group of children aged 3-6years with various respiratory symptoms.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Rambam Health Care Campus
• Treatments: Methacholine Chloride

Criteria

Inclusion Criteria:

• age 3- to 6-years

• respiratory diseases who were highly indicative of asthma diagnosis according to GINA guidelines [9]

• cough duration of more than 4 weeks

• normal chest auscultation and baseline FEV1>75% predicted for healthy preschool children, on the day of testing.

Exclusion Criteria:

• presence of other chronic respiratory conditions

• emergency room visit or the presence of respiratory infection within the last month

• oral or inhaled steroids or other anti-inflammatory medication taken in the last two weeks

• bronchodilator taken within 24-hours prior to the test.