Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients
Status:
Recruiting
Trial end date:
2028-12-01
Target enrollment:
Participant gender:
Summary
In recent years, an increasing number of retrospective and prospective observational studies
have indicated that a subset of rectal cancer patients may avoid surgery if they can achieve
a complete response to chemoradiotherapy. Prospective trials, including the previous Danish
Watchful Waiting trials (NCT00952926, NCT02438839) in early rectal cancer have demonstrated
high levels of organ preservation with dose-escalation, but it is unclear whether this was
primarily due to tumor stage or dose level.
The aim of the present study is to investigate if a higher dose of radiotherapy is superior
compared to a standard dose in patients with early rectal cancer undergoing chemoradiotherapy
with curative intent.