Standard Triple Therapy vs Sequential Therapy in Treatment of H Pylori Infection
Status:
Unknown status
Trial end date:
2013-01-01
Target enrollment:
Participant gender:
Summary
Traditionally, H pylori infection has been treated with conventional triple therapy. This
includes amoxicillin, clarithromycin and a proton pump inhibitor all given daily for 10-14
days. In Europe, the guidelines now advocate treatment of H pylori with sequential therapy
which is 5 days of amoxicillin therapy with proton pump inhibitor followed by 5 days of
clarithromycin, metronidazole, and proton pump inhibitor with better response rates. We
hypothesize that H. pylori resistance pattern and treatment response rates observed in Europe
will not be predictive of resistance patterns and response rates in the United States.
Phase:
N/A
Details
Lead Sponsor:
Dallas VA Medical Center
Collaborator:
Otsuka Pharmaceutical Development & Commercialization, Inc.