Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock

• Status: Terminated
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to determine the feasibility of conducting a large scale randomized controlled trial comparing standard and renally adjusted dosage of antibiotics in the septic shock patients with acute renal dysfunction. We will use Piperacillin as the prototype antibiotic in our study.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fraser Health
• Treatments: Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam

Criteria

Inclusion Criteria:

• Patients with septic shock according to the Surviving Sepsis Campaign

• Age > 19

• Most recent eGFR<40 mls/min

Exclusion Criteria:

• Pregnant

• Known chronic renal failure patients who are dialysis dependant

• Administration of systemic antibiotics > 1 dose

• Not expected to survive 28 days due to an underlying medical illness

• Allergy to Piperacillin/Tazobactam or any components of formulation within