Standardized Field Test for Marijuana Impairment II

• Status: Not yet recruiting
• Trial end date: 2024-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This research responds to NHTSA's request with a proposal to increase our understanding of smoked cannabis' (CNB's) acute effects on driving-relevant cognition and simulated driving performance, the persistence of these deficits over the hours after use, and the influence of prior experience with CNB on these effects. This extension study will aim to further investigate marijuana impaired behavior, using a similar design to our previous NHTSA Examine the Feasibility of a Standardized Field Test for Marijuana Impairment and the prior NIDA Neuroscience of Marijuana-Impaired Driving award, that used similar techniques and measures to quantify marijuana impaired automobile driving. We will be utilizing tasks and assessments that were shown to be strong indicators for cognitive and driving impairment in our NHTSA study.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Yale University
• Collaborators: Hartford Hospital; National Highway Traffic Safety Administration (NHTSA); National Institute on Drug Abuse (NIDA)
• Treatments: Dronabinol

Criteria

Inclusion Criteria:

• 18-55 yrs/ old

• Current driver's license and history of repeated highway vehicle driving experience (at least 2 years)

• Recent, recurrent CNB use and felt high when used

• Able to read, speak, and understand English

• Able and willing to provide written informed consent, and willing to commit to the study protocol

Exclusion Criteria:

• Current marijuana tolerance, desire to cut down, or cravings to use during periods of abstinence

• New CNB users who have not used at least once during their lifetime.

• Positive screen for drug and alcohol (except THC) on test day will result in rescheduling the appointment

• Former CNB users who are abstaining

• Pregnancy, breastfeeding, and ineffective birth control methods.

• History of adverse psychological or medical effects following cannabis use

• serious medical, neuro-ophthalmological, or neurological illness (i.e. cancer, seizure disorders, encephalopathy)

• History of head trauma with loss of consciousness > 30 minutes or concussion lasting 30 days.

• IQ <80 on the Wechsler Abbreviated Scale of Intelligence

• Inability to comprehend written instructions using the WRAT 4 reading achievement test

• Any medical/neurological condition that could compromise neurocognitive performance (i.e. epilepsy, multiple sclerosis, fetal alcohol syndrome)

• Uncontrolled, persistent high blood pressure

• Anyone deemed unsafe to study personnel for any reason