Stanford Accelerated Recovery Trial (START)

• Status: Terminated
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine whether administering Gabapentin prior to surgery affects duration of pain and opioid use post-surgery. The investigators aim to compare gabapentin to placebo in a prospective, randomized clinical trial in which patients will be followed post-surgery until pain resolves and opioid use ceases.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Treatments: Gabapentin; Lorazepam

Criteria

INCLUSION CRITERIA

• Age 18 to 75

• Undergoing a scheduled surgery

• English speaking

• Ability and willingness to complete questionnaires or use Palm Pilot

EXCLUSION CRITERIA

• Known kidney disease

• Currently receiving gabapentin or (pregabalin) lyrica already

• Cognitive impairment

• Previous history of excessive sedation or adverse reaction to gabapentin (not it was tried but ineffective for nerve pain)

• Coexisting chronic pain > 4/10 disorder in area other than surgical target

• Plan to move out of state

• Condition that would in judgment of team member make patient likely to be lost to follow-up

• Elevated suicidality

• Known pregnancy

• Current symptoms of ataxia, dizziness, or sedation

• Narrow angle glaucoma

• Severe respiratory insufficiency (ie, severe emphysema or chronic obstructive pulmonary disease)

• History of gastric bypass surgery and obstructive sleep apnea requiring continuous positive airway pressure (CPAP)