Statin Lowering Testosterone and Sexual Function

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Male

Summary

Statins may decrease serum testosterone levels via decreasing cholesterol. This longitudinal study detected the effects of rosuvastatin on free testosterone levels and sexual function in men with type 2 diabetes.

Methods:

Investigator enroll 150 men with type 2 diabetes and hypercholesterolemia. Biochemical assessments include serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, prolactin, thyroid-stimulating hormone, luteinizing hormone, follicle stimulating hormone, total testosterone and serum sex hormone binding globulin (SHBG). All parameters are measured before statin treatment, after 6 months of statin treatment and 6 months after discontinuing statin treatment. Scores of the sexual health inventory for men (SHIM) are also evaluated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Chang Gung Memorial Hospital
• Treatments: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Methyltestosterone; Rosuvastatin Calcium; Testosterone; Testosterone 17 beta-cypionate; Testosterone enanthate; Testosterone undecanoate

Criteria

Inclusion Criteria:

1. Type2 diabetes mellitus for more than 2 year.

2. Male subjects

3. Not received statin therapy for more than 1 year

4. Normal sexual activity

5. No hypogonadism history.

Exclusion Criteria:

1. Type 1 diabetes mellitus

2. Duration of diabetes less than 2 years and more than 10 years

3. Renal function impairment (creatinine level > 1.4 mg/dl)

4. Cancer or organic disease associated with hypogonadism,

5. With testosterone on antiandrogen drug therapy