There is evidence that the degenerative changes leading to aortic stenosis are caused by a
chronic inflammatory process. Furthermore the development of aortic stenosis is partially
dependent on typical cardiovascular risk factors. An inflammatory process as well as those
risk factors are amenable for medical therapy. As such the use of statins (HMG CoA reductase
inhibitors) would be an appealing concept to reduce both those risks for development of
aortic stenosis. Aim of this study is to evaluate the usefulness of statin therapy on the
progression of aortic stenosis.