Overview

Statins and CPAP in Adipose Tissue of OSA

Status:
Enrolling by invitation
Trial end date:
2023-07-01
Target enrollment:
0
Participant gender:
All
Summary
This study is aimed at examining the alterations in adipose tissue in obstructive sleep apnea (OSA) patients in response to treatment with atorvastatin in continuation with standard treatment with continuous positive airway pressure (CPAP).
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Treatments:
Atorvastatin
Atorvastatin Calcium
Criteria
Inclusion Criteria

- Participated in IRB 17-003825

- Apnea hypopnea index, AHIā‰„15

- Women of child-bearing age will be allowed to participate if they agree to use
acceptable birth control during the study period.

- More than 50% obstructive apneic events.

- TSH levels in range of 0.3-4.2 mIU/L

Exclusion Criteria

- Elevated ALT (>3 times upper normal limit)

- Fasting glucose >120 mg/dL

- Females planning to be pregnant in next six months will not be included in the study

- Known serious or hypersensitivity to HMG-CoA reductase inhibitors.

- Alcohol consumption >3 units/day