Stereotactic Radiation Therapy and Combination Chemotherapy in Treating Patients Undergoing Surgery for Locally Advanced Pancreatic Cancer

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Stereotactic radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Drugs used in chemotherapy, such as gemcitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving stereotactic radiation therapy together with combination chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving combination chemotherapy after surgery may kill any tumor cells that remain after surgery.

PURPOSE: This phase II trial is studying how well giving stereotactic radiation therapy together with combination chemotherapy works in treating patients undergoing surgery for locally advanced pancreatic cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität München
• Treatments: Gemcitabine; Oxaliplatin

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed adenocarcinoma of the pancreas or intrapancreatic bile duct carcinoma

• Overall view of image morphology and CA19-9 (< 500 U/L) demonstrating pancreatic cancer allowed if histologic/cytologic confirmation is unavailable

• Locally advanced disease, meeting 1 of the following criteria:

• Uncertain R0 resectability dependant on relation to portal vein, sinus confluens, superior mesenteric artery, and superior mesenteric vein (e.g., contact with portal vein, superior mesenteric vein, or arterial vessels, but < 180° encasement)

• Unresectable pancreatic cancer (e.g., contact with portal vein, superior mesenteric artery or arterial vessels, > 180° encasement)

• Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 1 cm by spiral CT scan or MRI

• Patients with no measurable disease may be assessed for feasibility only

• No distant metastases

PATIENT CHARACTERISTICS:

• ECOG performance status (PS) 0-1 OR Karnofsky PS 80-100%

• WBC ≥ 3,000/mm³

• Granulocyte count ≥ 2,000/mm³

• Platelet count ≥ 100,000/mm³

• Creatinine clearance > 30 mL/min

• Bilirubin ≤ 3.0 times upper limit of normal

• AST and ALT ≤ 2.5 times normal

• Alkaline phosphatase ≤ 2.5 times normal

• Not pregnant or nursing

• Negative pregnancy test

• Fertile patients must use effective contraception

• No secondary malignancy within the past 5 years that was not curatively treated

• No known intolerance to any of the study drugs

• No preexisting polyneuropathy > grade 1

• No active uncontrolled infection

• No cardiac insufficiency despite optimal medication

• No New York Heart Association class III or IV congestive heart failure

• LVEF ≥ 50% OR shortening fraction ≥ 25%

• No angina pectoris (at rest or under stress) unexplained by interventional cardiology within the past 6 months

• No myocardial infarction within the past 6 months

• No uncontrolled diabetes mellitus

• No other existing serious medical impairments that would preclude study compliance

PRIOR CONCURRENT THERAPY:

• No prior chemotherapy

• No prior radiotherapy to the abdomen