Steroid-Free Versus Steroid-Based Immunosuppression in Pediatric Renal (Kidney) Transplantation
Status:
Completed
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
Over the last 40 years, corticosteroids (steroids) have been an important part of drug
regimens used to prevent organ rejection and to maintain the immune health of individuals who
have received organ transplants. Unfortunately, the negative physical effects of steroids can
be severe, especially in children. The purpose of this study is to determine the safety and
effectiveness of a steroid-free treatment regimen for children and adolescents who have
received kidney (renal) transplants.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborators:
Astellas Pharma Inc Hoffmann-La Roche
Treatments:
Daclizumab Ganciclovir Ganciclovir triphosphate Immunoglobulin G Mycophenolate mofetil Mycophenolic Acid Prednisone Sulfamethoxazole Tacrolimus Trimethoprim Trimethoprim, Sulfamethoxazole Drug Combination Valganciclovir