Steroid Sparing Effect of Nasal Corticosteroid In Asthma And Rhinitis
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Up to 40% of patients with asthma have allergic rhinitis and treatment of nasal airway
inflammation with topical steroids improves the twitchiness of the airways
(hyperresponsiveness) and overall asthma control. The use of inhaled corticosteroids reduces
symptoms, severity of asthma attacks, improves quality of life, and reduces asthma related
deaths. Similarly, treatment of rhinitis with nasal steroids reduces symptoms and improves
quality of life. While there is evidence that combined treatment of the nose and the lungs
with topical steroids improves symptoms and underlying inflammation, it is unclear whether
such control can be achieved using a smaller dose of inhaled steroid in combination with
nasal steroid. It is therefore the intention of this study to evaluate if combination steroid
therapy (nose and lungs) has a steroid sparing effect in patients with asthma and rhinitis
using sensitive markers of airway inflammation.