Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.

• Status: Unknown status
• Trial end date: 2019-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the present study is to evaluate the efficacy of steroid therapy and hospital stay in patients with acute bronchiolitis at assiut university children hospital.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Albuterol; BB 1101; Budesonide; Dexamethasone; Dexamethasone acetate

Criteria

Inclusion Criteria:

1. Infants and young children aged from 3 months to 2 years with acute bronchiolitis.

2. Infants aged <12 months with respiratory rate over 60 breaths/min, childrens aged >12months with respiratory rate over 50 breaths/min.

3. Patients with an O2- saturation, breathing room air, under 95%.

4. Patients with apathy and/or refusal to eat.

5. Patients with normal white blood cell count for age.

6. Full term babies without chronic disease.

Exclusion Criteria:

1. Infants aged < 3 months, children aged >2 years

2. known or suspected asthma (by observing the good response to first dose of salbutamol nebulization especially among those with personal history of atopy).

3. Proven or suspected acute bacterial infection.

4. Presence of symptoms more than 7 days.

5. Previous treatment with corticosteroid by any route within 2 weeks.

6. Having a contra- indication to corticosteroid.

7. Severe cases requiring initial admission to intensive care unit with endotracheal intubation (in order to reduce confounding factors such as nosocomial infection or complication due to mechanical ventilation).

8. A previous history of intubation.

9. Premature babies (due to possible respiratory problems associated with prematurity).

10. Children with chronic cardiopulmonary diseases (Bronchopulmonary- dysplasia , Congenital Heart Disease and Cystic fibrosis)

11. Children with immunodeficiencies .

12. Children with neuromuscular disease.