Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
The mortality and neurological outcomes among out-of-hospital cardiac arrest survivors have
not improved despite the medical advances. The whole body ischemia/reperfusion injuries after
cardiac arrest mainly damaged the brain. To improve the neurologic outcome among those
patients, additional interventions would be warranted.
The investigators hypothesize that the combined use of cortisol, ascorbic acid (vitamin C),
and thiamine during the early post-resuscitation period would attenuate the whole-body
ischemia/reperfusion injuries among the out-of-hospital cardiac arrest survivors treated with
targeted temperature management.
Phase:
Phase 2
Details
Lead Sponsor:
Asan Medical Center
Collaborators:
Chung-Ang University Ewha Womans University Hanyang University Samsung Changwon Hospital Samsung Medical Center Seoul St. Mary's Hospital Wonju Severance Christian Hospital Yeouido St. Mary's Hospital