Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease

• Status: Completed
• Trial end date: 2016-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Steroid is commonly used to treat autoimmune disorders such as rheumatoid arthritis, lupus, and inflammatory bowel disease (Crohn's Disease and Ulcerative Colitis). However, its use is associated with numerous systemic side-effects, including diabetes, osteoporosis, and potentially significant mood changes. The investigators wish to determine how common patients with inflammatory bowel disease experience mood changes when they take steroid for their disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of British Columbia
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Outpatients with active Ulcerative Colitis or Crohn's Disease being initiated on oral prednisone for treatment of their IBD.

• Age 19 or greater

• Must be able to read and understand English

• Must be capable of providing informed written consent

Exclusion Criteria:

• Hospitalization within 2 weeks of study entry

• Liver cirrhosis with or without evidence of synthetic liver dysfunction

• Medications that interfere with corticosteroid metabolism (Clarithromycin, cyclosporine, imatinib, ketoconazole, and nefazodone)

• Psychiatric medication changes within 1 month of study entry

• Recreational drug use (due to their potential to alter mood) and/or alcohol abuse.