Steroids and Post-resuscitation Infectious (Septic) Complications

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Postresuscitation disease is characterized by post-insult systemic inflammation, adrenal insufficiency, and circulatory failure. Such severe pathology may be associated with increased susceptibility to infectious complications and increased risk of death due to postresuscitation septic shock. The latter may be attenuated by stress-dose steroids. In this re-analysis of synthesized randomized clinical trial (RCT) data, the investigators will use individual patient data from two prior RCTs of in-hospital cardiac arrest (NCT00411879 & NCT00729794), in order to determine the effect of stress-dose steroids on the severity of postresuscitation infectious complications, and more specifically, on the risk of septic shock-associated death.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Athens
• Collaborator: University of Thessaly
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Hydrocortisone hemisuccinate

Criteria

Inclusion Criteria:

• Adult patients with refractory inhospital cardiac arrest, defined as epinephrine requirement for ventricular fibrillation/tachycardia or asystole/pulseless electrical activity according to guidelines for resuscitation 2005

Exclusion Criteria:

• Age < 18 years

• Terminal illness or do-not resuscitate status

• Cardiac arrest due to exsanguination

• Cardiac arrest before hospital admission

• Pre-arrest treatment with intravenous corticosteroids

• Previous enrollment in or exclusion from the 2 studies included in the re-analysis