Steroids in Total Knee Arthroplasty

• Status: Suspended
• Trial end date: 2022-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication. The investigators will also determine if the subjects receiving the steroid will have better pain control and better postoperative outcomes after their surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Emory University
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate

Criteria

Inclusion Criteria:

• Patients undergoing primary total joint arthroplasty of the knee

• Adult patients ages 18-100 years

• Patients must have smart phone and/or device for app usage

Exclusion Criteria:

• Current chronic steroid use

• Patients undergoing revision knee surgery

• Patients ambulating preoperatively with assistive devices

• Patients with avascular necrosis of the operative knee

• Patients with a history of an adverse reaction to glucocorticoid steroids

• Patients unable to provide informed consent

• Patients with inflammatory arthritis

• Prisoners

• Current smokers

• Patients <18 years of age

• Any patient with a complicated postoperative course that requires transfer to the Intensive Care Unit (ICU) or to another facility for further management will be removed from the study.

• Any contraindication that would prevent the patient from being treated with the standard multimodal postoperative pain management regimen History of infection of surgical knee.

• Patients with diabetes.

• Patients that have an intolerance to Toradol.

• Patients that do not have smart phone and/or device for app usage