Strategy Therapy on Cancer Therapy-Related Cardiac Dysfunction

• Status: Recruiting
• Trial end date: 2025-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The investigators use the cancer registration system of National Cheng Kung University Hospital to timely screen and evaluate those patients having breast cancer or lymphoma to enroll patients to participate in this clinical trial. The investigators planned an earlier initiation of Sacubitril/Valsartan treatment on breast cancer and lymphoma patients before the chemotherapy, and starting therapeutic intervention by Sacubitril/Valsartan once the heart damage sign appeared via novel echocardiography. The investigators aim to assess the protective and therapeutic benefit of cardioprotective drugs on the cardiotoxicity of anti-cancer therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Cheng-Kung University Hospital

Criteria

Inclusion Criteria:

• Patients who are newly diagnosed with breast cancer or lymphoma and never accepted anti-cancer therapy

• Age 20-65 years old

• Systolic blood pressure ≥ 110 mmHg

Exclusion Criteria:

• End-stage renal disease (estimated Glomerulus Filtration Rate <15 mL/min/1.73 m2)

• Echocardiography Baseline left ventricle ejection fraction < 50%

• Allergy history to angiotensin receptor blockers

• Life expectancy < 1 year

• Pregnancy

• Unwilling to participate in this clinical study