Strengthening Instrumental Extinction to Prevent Smoking Relapse (VLNCCue)
Status:
Completed
Trial end date:
2017-09-08
Target enrollment:
Participant gender:
Summary
The central objective of the project is to evaluate the effect of incorporating smoking
related contexts into very low nicotine content (VLNC) cigarette extinction trials on
clinically relevant, smoking-related outcomes. Adult smokers interested in quitting smoking
(N=80) will be interviewed and trained to take pictures where they smoke cigarettes.
Following taking these pictures, participants will then be switched to smoke VLNCs while
wearing a 21 mg/d nicotine patch (EXT) for three weeks. During this 3-week treatment period,
half of the sample (n=40) will be randomly assigned to undergo six, 60-minute sessions of
multiple context extinction (MCE+) during which they will view smoking-related environments
and smoke their assigned cigarettes. The remaining 40 participants will undergo control MCE
(exposure to nature environments; MCE-) and smoke their assigned cigarettes. At the end of
the three weeks, participants will quit smoking and continue to wear the nicotine patch while
being followed during a 10-week abstinence period. Participants will also complete a
follow-up phone call 6 months after their quit day.
Phase:
N/A
Details
Lead Sponsor:
Francis McClernon, Ph.D.
Collaborators:
National Institute on Drug Abuse (NIDA) National Institutes of Health (NIH)