Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients

• Status: Unknown status
• Trial end date: 2021-04-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of phase II/III study: Determining the Overall Survival（OS）of Chlorogenic acid for injection comparing to in the advanced Glioblastoma Patients through study completion（an average of 18 months）after the first dose of chlorogenic acid for injection and Lomustine.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
• Treatments: Lomustine

Criteria

Inclusion Criteria:

1. Age ≥ 18;

2. KPS ≥ 60;

3. Recurrent GBM;

4. Estimated lifetime ≥ 3 months；

5. Female patients with negative pregnant test, and male/female patients of reproductive age without pregnancy planning in the next 12 months;

6. Volunteered for the phase 2 trial and sign the informed consent without protest.

Exclusion Criteria:

1. Patients who have received the therapy of chemotherapy or radical radiotherapy within 1 month before enrollment;

2. Pregnant or breast-feeding women, or patients(male and female) who have pregnancy plan;

3. Patients who had received a therapy of another investigational drug within 1 month；

4. Known active hepatitis B/hepatitis C, positive HIV/ syphilis antibody;

5. Patients who have received therapy of major surgery within 4 weeks or biopsy surgery within 1 week before enrollment;

6. Patient who need long term treatment of cortical hormone or other immunosuppressive drugs such as visceral organ transplanters；

7. Patients who have sufficient baseline organ function and whose laboratory data can meet the following criteria at the enrollment:1)PLT count<80×10~9/L； 2)NEUT# count<1.5×10~9/L ；3)HGB count<90g/L；4)Total bilirubin >1.5 times of ULN；5)ALT/AST >1.5 times of ULN；

8. History of drug abuse；

9. Patients who was treated with Immunologic drugs（DC/CIK/CTL/PD-（L）1） in 3 months;

10. Patients who are false progressers；

11. Patients who can not be received MRI examination；

12. Patients who had severe trauma or infectious diseases within 4 weeks；

13. Patients who had cerebral stroke or Transient ischemic attack within 6 months；

14. Patients who were performed important operations within 4 weeks；

15. Uncontrollable psychopaths;

16. Patients who had other advanced cancers within 5 years；

17. Patients who had grade III or IV heart failure within 6 months；

18. Other patients judged ineligible for enrollment in the study by the investigator (sub-investigator).