Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

• Status: Terminated
• Trial end date: 2006-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The use of oral antibiotics alone to treat inflammatory acne provides little to no long term therapeutic benefit.

Acne relapse rates can be reduced by using topical tretinoin 0.01% in conjunction with minocycline, thereby increasing the therapeutic effect of the oral antibiotic.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Derm Research @ 888 Inc.
• Collaborator: Stiefel, a GSK Company
• Treatments: Minocycline; Tretinoin

Criteria

Inclusion Criteria:

• Provision of written consent

• Either sex

• Any age

• Diagnosis of acne vulgaris with a minimum of 20 inflammatory acne lesions on the face.

Exclusion Criteria:

• Known hypersensitivity to tetracyclines

• Use of any oral antibiotics in the previous 3 months

• Pregnancy, breast-feeding or lactating

• Inability or unwillingness to comply with the requirements of the protocol, or agree to the use of their data as determined by the investigator.

• Concomitant medical condition which, in the investigator's opinion, may confound the study results or interfere with study assessments or outcomes.

• Patients with severe acne on the chest, back or trunk.