Study Comparing Doses Of An Experimental Glucocorticoid Compound To Prednisone And Placebo In Rheumatoid Arthritis
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to compare the safety and efficacy of multiple doses of
PF-04171327, an experimental glucocorticoid drug, to prednisone at 5 mg or 10 mg and placebo
in the treatment of rheumatoid arthritis. All subjects will also be receiving background
treatment of methotrexate for their rheumatoid arthritis. Study medication will be given for
eight weeks followed by a 4 week period during which the dose of study medication will be
gradually reduced. The efficacy of the study medications will be determined by assessing
severity of the rheumatoid arthritis during the study and safety will be determined by
adverse event reporting, laboratory tests and biomarker analysis.