Study Comparing Two Immunosuppressive Regimens in De Novo Renal Allograft Recipients
Status:
Completed
Trial end date:
2005-01-01
Target enrollment:
Participant gender:
Summary
Evaluate renal graft function (based on the calculated Glomerular Filtration Rate) at 12
months after transplantation in patients receiving either a regimen of sirolimus plus
mycophenolate mofetil following an antibody induction (RATG) or a standard regimen combining
tacrolimus plus mycophenolate mofetil, both regimens including corticosteroids in patients
undergoing renal allograft transplantation. In addition, the two treatment groups will be
compared with respect to the incidence of acute rejection at 3, 6 and 12 months following
transplantation, and the patient and graft survival at 6 and 12 months after transplantation.
The safety of sirolimus plus mycophenolate mofetil following an antibody induction (ATG) will
be evaluated beginning in the immediate post-operative period.